The silkworm has serrapeptase (also known as Serratio Peptidase or serratiopeptidase), a proteolytic enzyme.
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Serrapeptase or serratiopeptidase, isolated from the microorganism Serratia E15,
is naturally present in the silkworm intestine which allows the emerging moth to dissolve its cocoon.
Clinical use of serrapeptase in Europe and Asia spans over twenty five years.
The proteolytic enzyme serrapeptase is widely used in clinical practice in Japan.
We investigated the effect of serrapeptase on sputum properties and symptoms in patients with chronic airway diseases.
This study was an open-labeled trial with a non-treatment control group.
Patients were randomly assigned to oral treatment and without serrapeptase 30 mg/day for 4 weeks.
Patients collected sputum samples for about 4 hours in the morning on the day the trial began and 4 weeks later.
Part of each sputum sample was weighed and then completely dried and reweighed.
The percentage solid component, viscosity and elasticity of the sputum were measured.
Mucociliary transportability index was measured using ciliated bovine trachea ex vivo.
CONCLUSIONS: serrapeptase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers and altering the viscoelasticity of sputum in patients with chronic airway diseases.
